We develop and utilize systematic approaches to accelerate biomedical insights and expand their impact on human health.
Solving complex biomedical questions takes more than just collecting more data—it requires innovative assays, novel study systems, and automated processes that produce consistent, high-quality results. Given the breadth of biomedical research, we often need custom solutions and infrastructure for unique samples, readouts, and analyses. At HTS, we aim to democratize data production and analysis so we empower all researchers to extract meaningful insights.
We create automation-friendly protocols for biochemical and cell-based assays.
We screen chemical and genetic libraries for target discovery, drug repositioning, and mechanistic insights. Our instruments facilitate combinatorial and personalized panels.
We program instruments to carry out liquid handling and readout generation steps consistently. Our user-friendly instruments are open for trained users.
We develop project-specific data portals and functional backends to support analysis and reporting.
We engage in multi-team research projects, and assist with study design and grant writing.
We strive for everyone to make the most out of our resources by providing training on instruments and data analysis.
Contact us with a brief description of the study. We'll schedule an initial consultation to align on goals and experimental design.
Yes. We actively collaborate with external investigators, hospitals, and industry partners.
For collaborative projects, pricing depends on the complexity, scope, and duration of the project. We recommend starting with an initial consultation so we can better understand your goals and provide a tailored cost estimate. Contact us to schedule a time.
Some instruments are also available for independent use when not reserved for automation or collaborative projects. After completing training, approved users may operate these instruments on a walk-up basis. Base rates for walk-up access are available on the KI SBC pricing page .
Absolutely. Partnering on grant proposals is often the most effective and sustainable way, especially for complex or longer-term projects. We frequently collaborate with investigators during the proposal writing stage and can provide letters of collaboration, budget estimates, and tailored descriptions of our scientific and technical capabilities. For more substantial efforts, we work with investigators to design the specific aims and approach, serving as co-investigators to reflect the active scientific contributions and resource commitment of the HTS team. Contact us early in your planning process to align timelines and scope.
We deliver both raw and processed data, clearly annotated and organized for reproducibility. While MIT users can request direct delivery to their network drives, our preferred method is secure cloud-based delivery with role-based access control to ensure reliable and accessible data sharing — including for external collaborators.
We routinely provide data analysis as part of our workflows, including hit calling, dose-response modeling, high-content phenotyping, and custom machine learning-based solutions. We also develop custom analytical pipelines and interactive visualizations that would become available on our data portal. These can be publicly accessible or restricted to specific collaborators.
As part of our mission to democratize data science, we're always happy to teach researchers how to access, interpret, and analyze the data using open tools and reproducible methods.
We support a wide variety of assay types thanks to our diverse range of instruments. This includes high-content imaging assays, luminescence-based reporter assays, fluorescence intensity and FRET assays, Alpha assays (such as AlphaLISA and AlphaScreen), viability and proliferation screens, enzymatic activity assays, and compound combination matrices.
Contact us to discuss your specific needs.
We currently have a collection of approximately 3000 annotated, targeted FDA-approved compounds. Additionally, we offer a library of 50,000 novel chemical entities (NCEs) that explores a diversity of stereochemical and structural parameters.
We also work with user-supplied libraries ranging from a few compounds/materials to large collections. We can assist with formatting to ensure compatibility with our systems.
Yes. We support screens using genetic perturbation libraries such as CRISPR, shRNA, and siRNA. Our cell culture facility is Biological Safety Level BL-2+ certified and equipped to safely handle lentiviral transduction workflows. We can assist with library formatting, transduction optimization, and downstream assay integration.
We work with a wide range of sample types, including live and fixed cells (adherent or suspension), patient-derived organoids and primary cells, and fresh tumor biopsies (solid or fluid). We also support biochemical assays, and have handled user-submitted small molecules, PROTACs, antibodies, nanoparticles, and nucleic acids. Compatibility with automation and high-throughput formats can vary depending on the sample type, and we work closely with users to adapt protocols and ensure successful integration into screening workflows.
Yes. We specialize in developing rapid, high-throughput functional screening assays tailored to low-input clinical samples in a research setting. Our operation supports time-sensitive workflows, and we routinely work with clinicians to generate data within 6-24 hours of sample acquisition. We also leverage machine learning to prioritize the most actionable hypotheses for testing, maximizing biological insight when sample quantity is limited.
Yes. Contact us to discuss your specific needs.
